PROSPECTIVE HLA-DP TYPING OF A CADAVERIC ORGAN DONOR FOR KIDNEY TRANSPLANTATION – A CASE REPORT

Marija Burek Kamenaric; Marija Maskalan; Ivana Kovacevic Vojtusek; Zorana Grubic; Renata Zunec

Marija Burek Kamenaric Tissue Typing Centre, Clinical Department of Transfusion Medicine and Transplantation Biology, University Hospital Center Zagreb, Zagreb, Croatia
Marija Maskalan Tissue Typing Centre, Clinical Department of Transfusion Medicine and Transplantation Biology, University Hospital Center Zagreb, Zagreb, Croatia
Ivana Kovacevic Vojtusek Department of Nephrology, Arterial Hypertension, Dialysis and Transplantation, University Hospital Centre Zagreb, Zagreb, Croatia
Zorana Grubic Tissue Typing Centre, Clinical Department of Transfusion Medicine and Transplantation Biology, University Hospital Center Zagreb, Zagreb, Croatia
Renata Zunec Tissue Typing Centre, Clinical Department of Transfusion Medicine and Transplantation Biology, University Hospital Center Zagreb, Zagreb, Croatia

Keywords: HLA-DP typing, HLA-DP DSA, cadaveric kidney transplantation, Croatia

Abstract

In this paper, we present the case of an HLA-DP immunized patient in the process of kidney re-transplantation for which potential pre-transplantation HLA-DP donor-specific antibodies were detected. For that reason, for the first time in our laboratory practice, prospective cadaveric donor HLA-DP typing was performed during the process of kidney allocation. This case, together with other international study reports and protocols of some transplantation programs, points to the importance of introducing pre-transplant HLA-DP typing in cadaveric kidney transplantation in Croatia.